What is Ozone Therapy? Ozone therapy is a type of treatment performed by giving an ozone/oxygen mixture to the body's circulatory system in order to support the treatment of various diseases. This treatment can be used for therapeutic purposes because it prevents the reproduction of microorganisms caused by orthopedic infections in joints and tendons. How Is Ozone Therapy Done? Major ozone therapy can be applied by intravenous administration of an ozone/oxygen mixture to the body, while in minor ozone therapy, it can be applied to open wounds with a bag system and directly on the wound in a closed system with special bags.